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MACULAR DEGENERATION STUDIES
1. Risk of developing advanced disease was reduced by about 25% in those with intermediate damage from taking 500 mg of vitamin C, 15 mg of beta carotene, 400 IU of vitamin E and 80 mg of zinc on a daily basis. Ferris, et al. Archives of Opthalmology; Oct 01. (Ed. Note: This study is not yet available online. We believe a more absorbable form of zinc, such as Opti-zinc, would provide better results with a lower dose, as well as substituting lutein for beta carotene. High doses of zinc can cause anemia.)
2. A preliminary study showed those consuming lutein from either spinach or supplements demonstrated improvement of some of the early vision loss from "dry" macular degeneration. Richer, J. Amer Optom Assoc; Jan 1999.
3. Consuming 6 mg of the caroteinoid lutein (w/ it's co-nutrient zeaxanthin) daily (Ed. Note: equiv. to 4-8 ounces of spinach daily, depending on reference) for five months was shown to significantly increase macular pigment density, which protects from harmful blue wavelength light believed to be most responsible for macular degeneration. Landrum, et al. Exp Eye Res 1997 Jul;65(1):57-62
4. High macular pigment density was associated with the retention of youthful visual sensitivity, which suggested that increasing macular pigment may retard age-related declines in visual function. Hammond, et al. Invest Ophthalmol Vis Sci 1997 Aug;38(9):1795-801.
5. Persons who had the lowest
serum levels of lycopene, the most abundant carotenoid in the serum, were
twice as likely to have macular degeneration when compared to those with
the highest levels. Mares-Perlman,
et al. Arch Ophthalmol 1995 Dec;113(12):1518-23
6. Those consuming lutein rich
foods (spinach and collard greens) five days per week were 8 times less
likely to develop macular degeneration as those consuming them once per
et al. JAMA 1994 Nov 9;272(18):1413-20
7. The ARMD population manifested decreased intake of vitamin E, magnesium, zinc, vitamin B6 and folic acid. Patients with advanced ARMD taking antioxidants twice daily maintained vision in their better functioning eyes significantly better than those taking a placebo. Richer, J Am Optom Assoc 1996 Jan;67(1):12-29 J Am Optom Assoc 1996 Jan;67(1):30-49
8. Smokers with early macular degeneration who consumed the lowest amounts of carotenoids were nearly 6X as likely to develop advanced macular degeneration than those consuming the highest amounts. Seddon, et al. J. Amer Med Assoc; 1994.
9. In a clinical trial 60% of
subjects with ARMD or diabetic macular edema who received 500 mg of vitamin
C, 400 IU of vitamin E, 15,000 IU of beta carotene and selenium showed
either improvement or no further progression of their disease. So
Med J, 1987.
10. The evidence suggests that carotenoids and antioxidant vitamins may help to retard some of the destructive processes in the retina and the retinal pigment epithelium which are responsible for age-related degeneration of the macula. Am J Clin Nutr 1995 Dec;62(6 Suppl):1448S-1461S
11. The minerals copper and zinc are required to synthesize superoxide dismutase and other enzymes in the retina which scavenge free radicals, preventing the oxidative damage which plays a role in the development of drusen, an early sign of Age-Related Macular Degeneration. Olin, et al: Proc Soc Exp Biol Med 1995 Apr;208(4):370-7
12. Glutathione and its related enzyme precursor amino acids (N-Acetyl-Cysteine, L-glycine, and glutamine and selenium) are protective against damage to human retinal pigment epithelium cells. Sternberg, Davidson, Jones, et al. Invest Ophthalmol Vis Sci 1993 Dec;34(13):3661-8
13. Quercetin protected bovine retinas in vitro from induced lipid peroxidation, especially when combined with vitamin E, suggesting a potential protective effect in age-related macular degeneration. Ophthalmic Res 1996;28(3):184-92.
14. Deficiency of taurine, an amino acid, has been shown to lead to retinal degeneration and supplementing it has been used with some success to prevent, treat and stabilize retinal changes. Altern Med Rev 1998 Apr;3(2):128-36. Oftalmol Zh 1989;(8):463-5 Brain Res Brain Res Rev 1991 May-Aug;16(2):151-69 J Neurosci Res 1987;18(4):602-14
15. After 18 months, subjects with macular degeneration who took antioxidants on a consistent basis were 2.5X more likely to improve on visual acuity testing, and four times less likely to deteriorate in their worst eye, compared to those who took them less consistently. Olson, et al. J. Cat Refr Surg, Mar 1991.
16. Patients with confluent soft drusen, or "pre-wet" ARMD, were found to have evidence of vitamin B6 deficiency. B. Lane, Ann Mtg Amer Coll of Nutrition, 1991.
17. General measures for prevention and remediation of macular degeneration would include a combination of supplementation with trace elements, antioxidants and other vitamins, ...increasing physical fitness, improving nutrition (e.g. avoiding hydrogenated oils), abstaining from smoking, and protection from excessive light exposure. Eur J Med Res 1997 Oct 30;2(10):445-54
18. There is an association between both low serum selenium levels and current smoking status and the development of age-related macular degeneration. Doc Ophthalmol 1992;81(4):387-400 Mayer, et al. Acta Ophthalmol Scand 1998 Feb;76(1):62-7
19. There was an inverse relationship between dietary pro-vitamin A carotenoid and vitamin E consumption and the incidence of large macular drusen, as well as between zinc levels and the incidence of retinal pigment abnormalities. Am J Epidemiol 1998 Jul 15;148(2):204-14
20. The evidence suggests that carotenoids and antioxidant vitamins may help to retard some of the destructive processes in the retina and the retinal pigment epithelium that lead to age-related degeneration of the macula. Snodderly, Am J Clin Nutr 1995;62(6 suppl):1448S-61S
21. Subnormal zinc and/or vitamin E serum levels may be associated with as much as an 82% increased risk of advanced age-related macular degeneration. Vitamin C and lipoic acid help to recycle vitamin E in the retinal tissues. Ishihara, et al. Nippon Ganka Gakkai Zasshi 1997 Mar;101(3):248-51. Delcourt C. et al. Arch Ophthalmol 1999 Oct;117(10):1384-90 Stoyanovsky DA, et al. Curr Eye Res 1995 Mar;14(3):181-9
22. In a study of adults over 60 there was found to be a significant link between risk of macular degeneration and low blood levels of vitamin E as well as increased sun exposure. Belda, et al Mech Ageing Dev 1999 Mar 1;107(2):159-64
23. A statistically significant improvement in visual acuity was observed after treatment with Ginkgo biloba extract in a double blind, placebo controlled study of macular degeneration patients. Lebuisson DA, et al. Presse Med 1986 Sep 25;15(31):1556-8
24. Those consuming fish more than once per week were only half as likely to develop macular degeneration than those consuming it less than once per month. Those consuming the highest amount of cholesterol in their diet were 2.7 times more likely to develop advanced macular degeneration. Smith, et al. Arch Ophthalmol 2000 Mar;118(3):401-4
25. Dietary enzymes increase glutathione synthesis which can prevent free radical-induced apoptosis (cell suicide) and may help prevent or treat AMD. Progress in Retinal and Eye Research, 2000, Vol. 19, Iss.2 pp 205-221 (No abstract available)
FOR INFORMATION ABOUT THE NUTRITIONAL
1. In a study of open angle glaucoma patients who received 150mg of Alpha Lipoic Acid each day, 45-47% of the eyes had enhancement of color visual fields and visual sensitivity when compared to controls using only topical medical therapy. More advanced cases had an even better response compared to their controls. Filina, et al., Vestn Oftalmol 1995 Oct-Dec;111(4):6-8
2. Pretreatment with alpha lipoic acid has been found to reduce neuronal damage from excitotoxic damage from cyanide, glutamate and iron ions, demonstrating a strong neuroprotective effect for this substance in nerve tissue. It may be useful in treating glaucoma. (Ed. Note: Recent evidence points to the importance of neuroprotection against glutamate in glaucoma patients, with many medications now heavily promoting this property!) J Cereb Blood Flow Metab 1995 Jul;15(4):624-30 Altern Med Rev 1998 Aug;3(4):308-11 (Other ALA/Neuroprotective Studies)
3. The eyes of open angle glaucoma patients were found to have significantly lower vitamin C levels, as well as higher levels of lipic peroxidation byproducts compared to normals. Aleksidze, et al. Oftalmol Zh 1989;(2):114-6
4. Patients suffering from open angle glaucoma and normal-tension glaucoma who were given magnesium twice daily showed improvement of the visual field and reduced peripheral vasospasms (which can cause glaucoma, stroke and heart attack) after four weeks of treatment. Gaspar, et al; Ophthalmologica 1995;209(1):11-3
5. Glaucoma patients treated with vitamin B12 for over 5 years demonstrated better visual acuity and better overall control of their disease. Glacome, 1992; Nippon Ganka Kiyo. 1965 Mar.; Oftalmol Zh. 1965; 20(6); Klin Oczna 1974 Nov;44(11):1183-7
6. Besides beta carotene, other carotenoids found in dark green leafy vegetables appear to be much more essential to the health of the eye. Several studies have shown that lutein and zeaxanthin supplements may slow vision loss in glaucoma, and in some cases improve eyesight. Science News, Volume 146.
7. Anthocyanosides, compounds found in the herb bilberry, were shown to markedly improve vascular resistance of the capillary wall in the ciliary body of the eye (the source of excess fluid production). Boll. Ocul. 65 789-95, 1986
8. Chronic open angle glaucoma patients had a statistically significant lower thiamine blood level than controls along with poor absorption of that nutrient. Asregadoo, Ann Ophthalmol 1979 Jul;11(7):1095-1100
9. Lipoic acid may be useful in the treatment of glaucoma and may help prevent ischemic optic nerve damage. Altern Med Rev 1998 Aug;3(4):308-11
10. The scientific literature supports recommending lipoic acid in complex with vitamins B1, B2, B5, B6 (pyridoxal phosphate), and vitamin C to glaucoma patients. Filina, AA & Sporova, NA. Vestn Oftalmol 1991 May-Jun;107(3):19-21
11. Vascular obstruction and hindrance of the blood flow and impaired nutrition of neuronal tissue might be the primary causes of glaucoma. Sonnsjo & Krakau, Acta Ophthalmol (Copenh) 1993 Aug;71(4):433-44
12. Ginkgo biloba is a potentially important agent in the treatment of glaucoma. It improves central and peripheral blood flow, reduces vasospasm, reduces serum viscosity, has antioxidant activity, platelet activating factor inhibitory activity, and inhibits apoptosis and excitotoxicity - all factors in preventing glaucoma vision loss. (Ed. Note: magnesium also has been shown to decrease peripheral vasospasms, improving blood flow and is neuroprotective, as well.) Ritch R. Med Hypotheses 2000 Feb;54(2):221-35
13. The fatty acid DHA (abundant in fish oil), along with B Complex and vitamin E were shown to be helpful in preventing or delaying vision loss associated with glaucoma. Cellini M, et al., Acta Ophthalmol Scand Suppl 1998;(227):41
14. Ginkgo biloba extract (40mg, three times daily), increased diastolic blood flow by 23% in the ophthalmic artery in glaucoma patients and may be helpful in protecting the optic nerve from further damage and subsequent visual field loss. Chung HS, et al. J Ocul Pharmacol Ther 1999 Jun;15(3):233-40 (Ed. Note: Ginkgo must be used with caution by those taking Coumadin, as it may increase its effect - possibly eliminating the need for it??)
15. Besides alpha lipoic acid, other nutrients which are neuroprotective include vitamin E, ginkgo biloba, pycnogenol (from grape seed extract or pine bark), and flavonoids. Kobayashi MS, et al. Free Radic Res 2000 Feb;32(2):115-24
FOR INFORMATION ABOUT THE NUTRITIONAL
DIABETIC EYE STUDIES
1. Alpha Lipoic Acid can significantly reduce diabetic cataract formation, as well as neuropathy, and would seem to be an ideal neuroprotective substance in the treatment of all oxidative brain and neural disorders involving free radical processes. Packer, L., Ann N Y Acad Sci 1994 Nov 17;738:257-64 Packer, L. Free Radic Biol Med 1997;22(1-2):359-78
2. Vitamin E significantly improved glucose tolerance in non-insulin dependent diabetics, which should very likely result in fewer diabetic complications. Paolisso, G, et al. Am J Clin Nutr 1993; 57:650-56.
3. Diabetic patients with high serum magnesium levels were less likely to develop severe diabetic retinopathy compared to those with low levels. Diabetes 1978 Nov;27(11):1075-7.
4. Chromium, high-dose vitamin E, magnesium, soluble fiber, and possibly taurine appear likely to lessen risk for macrovascular disease (retinopathy) in diabetics. McCarty, Med Hypotheses 1997 Aug;49(2):143-52.
5. Bioflavonoids, including those from bilberry extract, were found to normalize blood vessel permeability in diabetic patients, significantly reducing the risk of diabetic retinopathy. Long term use of multiple antioxidants inhibits the development of early stage diabetic retinopathy. Valenci, et al. Diabet Med 1996 Oct;13(10):882-8. Detre, et al. Clin Physiol Biochem 1986;4(2):143-9 Kowluru RA, et al. Diabetes 2001 Aug;50(8):1938-42
6. Seven of fifteen patients with Type I diabetic retinopathy who were given vitamin B12 along with their daily insulin injections were found to have complete regression of retinal signs after 12 months. Kornerup T, Strom L. Acta Paediatr 1958.
7. 79% of 37 patients with visible diabetic retinal abnormalities improved after taking 160 mg of bilberry extract twice daily, compared to 0% of the placebo control group, and 86% of those with abnormalities of angiography findings showed moderate to considerable improvement. (These improvements were noted within one month.) Perossini, et al. Ann Ottalmol Clin Ocul 1987.
8. 73% of type I and II diabetics who took chromium supplements reduced their requirement for insulin or oral hypoglycemic agents. Taking chromium and niacin together reduced fasting blood sugar levels and improved glucose tolerance. J Trace Elem Exp Med 1995: 8:183-90; Urberg M, Zemel MB, Metabolism 1987; 36:896-99.
9. Low magnesium levels might increase the risk of ischemic heart disease and severe retinopathy in diabetics, while chromium increases insulin sensitivity and raises the 'good' HDL cholesterol. Tuvemo, T. Pediatrician 1983-85;12(4):213-9
10. Low serum carotenoid levels were found to be directly related to an increased risk for developing insulin resistance and diabetes. Ford, et al. Am J Epidemiol 1999 Jan 15;149(2):168-76
11. Both Panax and American ginseng was shown to normalize glucose tolerance tests, and reduced blood sugar spikes in Type II diabetics after consumption of a sugar solution. Vuksan V, et al., Arch Intern Med 2000 Apr 10;160(7):1009-13
12. In one study all 38 patients with insulin-dependent diabetes were required to lower their insulin dose to avoid hypoglycemia after taking 200mg of Gymnema Sylvestre extract twice daily. Shanmugasundaram ER, et al. J Ethnopharmacol 1990 Oct;30(3):281-94
FOR INFORMATION ABOUT THE NUTRITIONAL
1. Subjects taking vitamin C supplements for more than 10 years had a 45-77% lower risk of early lens opacities (cataracts) and 83% lower risk of moderate lens opacities. The higher the serum levels, the lower the risk of cataracts. Jacques, et al. The American Journal of Clinical Nutrition, Oct. 1997. S.E. Hankinson, et al. 1992. BMJ: 305: 335-339. Simon JA, Hudes ES J Clin Epidemiol 1999 Dec;52(12):1207-11
2. Vitamin E, vitamin C, alpha-lipoic acid, and taurine appear to offer protection against lens damage caused by low level radiation. Bantseev, et al. Biochem Mol Biol Int 1997 Sep;42(6):1189-97.
3. Dietary lutein and cryptoxanthin were associated with 70% lower risk of nuclear cataracts in those under age 65. Lyle, et al. Am J Clin Nutr 1999 Feb;69(2):272-7.
4. Dietary intake of protein, vitamins A, C, E, and carotene, niacin, riboflavin, and thiamine significantly decreased the risk of all cataract types. (Combining a variety of antioxidant nutrients produced the greatest effect.) Cumming RG, et al. Ophthalmology 2000 Mar;107(3):450-6 Leske, et al. Arch Ophthalmol 1991 Feb;109(2):244-51.
5. Vitamin E taken with bilberry extract stopped the progression of senile cortical cataracts in 97% of the eyes of human subjects. Ann Ottalmol Clin Ocul, 1989.
6. Low blood levels of vitamin E were associated with approximately twice the risk of both cortical and nuclear cataracts, compared to median or high levels. Vitale, et al. Epidemiology 1993 May;4(3):195-203
7. Smokers were 2.6 times as likely to develop posterior subcapsular cataracts than nonsmokers. Hankinson, et al. JAMA 1992 Aug 26;268(8):994-8
8. Patients with senile cataracts were found to have significantly lower blood and intraocular levels of the mineral selenium than controls. Karakucuk S, et al. Acta Ophthalmol Scand 1995 Aug;73(4):329-32
9. Alpha lipoic acid can help prevent cataract formation as well as nerve degeneration and radiation injury. Packer, et al. Free Radic Biol Med 1995 Aug;19(2):227-50
FOR INFORMATION ABOUT THE NUTRITIONAL
RETINITIS PIGMENTOSA STUDIES
2. The essential fatty acids alpha-linolenic acid and DHA may be required for those with retinitis pigmentosa to support normal functional development of the retina. Uauy R, et al. Lipids 1996 Mar;31 Suppl:S167-76
3. A diet high in polyunsaturated fats (e.g. corn oil), and low in vitamin E, selenium, sulfur-containing amino acids (e.g. taurine, methionine), and chromium were related to a build up of pigment which mimics one type of retinitis pigmentosa. Katz, et al. Invest Ophthalmol Vis Sci 1978. Pang J, et al. Jpn J Ophthalmol 2001 Nov-Dec;45(6):672-6
4. Lutein supplementation in high doses improved both visual acuities and visual fields after 2-4 weeks of treatment in 16 subjects, and was especially effective in blue eyed individuals. Dagnelie G., et al Optometry 2000 Mar;71(3):147-64
5. Vitamin B3 may be a potential therapeutic agent for the treatment of retinal degeneration, including retinitis pigmentosa. Kiuchi K, et al Exp Eye Res 2002 Mar;74(3):383-92
DISCUSSION AND COMMENTS
|While these studies are certainly promising,
we must stress that there are no widely accepted or proven cures for degenerative
eye disease and some studies
have even shown no positive results. (This often can be attributed
to their use of the wrong form of nutrients or inadequate doses).
More studies are indicated and being undertaken at centers all over the
world. A few small, nonpublished studies have shown that as many
as 80% of early macular degeneration patients have stablized for several
years after beginning supplements, but these are still preliminary.
Other factors affect the progression of eye diseases, including too many saturated and "trans" (hydrogenated) fats and not enough Omega 3 fats. Also certain medications, toxins (including aspartame, aka "Nutrasweet" click for article, and MSG), smoking, excess sunlight exposure, poor drinking water and air quality, as well as lack of exercise and the resultant decreased blood flow to the ocular tissues can affect visual outcome. (See our "Tips" report on The EYE SITE's Home Page for more on these other factors.)
The overwhelming body of evidence points to significant beneficial effects of nutritional supplementation for most degenerative eye conditions. Important to remember is that most of the above studies used blood levels and food intakes associated with a normal diet. Taking supplements with dosages significantly higher than available in a normal diet may have a much more protective effect than dietary levels alone. With so little risk, and the other potential health benefits from taking nutritional supplements, it would certainly seem prudent to try them, especially for macular degeneration where there are no real options.
Once the damage is done it cannot be reversed (except to a small degree), so prevention and early intervention is essential, especially if we have a family history of the disease. Of course, it's important to slow further progression at any stage of development. It is also important to be followed closely by a nutritionally knowledgeable eye doctor when starting nutritional supplements and one should never discontinue prescribed medications without your regular doctor's approval.
Most of the nutrients mentioned above can be purchased individually or in combination at your local healthfood store, but it can be very confusing for the lay person or even health professionals to separate the facts from the hype. For this reason, we've compiled a Comparison Chart for the two best ocular nutrition supplements which we've come across, as well as the two most popular brands given away as samples by many eye doctors. Forget the hype and compare them head-to-head yourself by going to the Ocular Nutrition Comparison Chart by clicking on this underlined text.
May we count on you to help us? Since the vast majority of optometrists and ophthalmologists find it very difficult to keep up with all the new research, would you please share this information with your own eye doctor? (Emailing or printing this page out and handing or faxing it to him/her are the best ways.) We know that, with your help, we can reach more eye doctors and keep them up-to-date on promising new techniques for preserving eyesight and health. We also would appreciate your requesting that other health websites you visit link to our studies. We thank you in advance for your kind efforts!
We now are building up a network of progressive eye physicians who are aware of the research on this page and want to keep abreast of important new studies as they are published.
If your doctor is unwilling to look over the research we've summarized above, perhaps you would be wise to consult with one of the doctors listed on our RECOMMENDED EYE DOCTORS WEBPAGE. If you feel your doctor should be listed and he isn't, why not encourage him to apply for a free listing? He just has to pass a short quiz to prove he has read the research.
And if you haven't done so already, we highly recommend you read the remarkable nutrition research against cancer (50% lower death rates from taking one nutrient), heart disease (77% reduction in heart attacks from another nutrient), stroke (73% reduction in risk) and many other health conditions, by clicking here => GENERAL HEALTH RESEARCH.
Thank you for visiting us, and please bookmark us and visit often so you can keep abreast of new research as it's released!
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George L. Schmidt, O.D.
Founder, I-CARE Network of Physicians
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